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Figure 1.

In 1920, during a meeting of the New York Pathological Society, James Ewing described an unusual tumor in a 14-year-old girl as a "diffuse endothelioma of bone." The tumor had initially been diagnosed as an osteosarcoma, but its architecture, the morphologic features of its cells, and its marked…

To the Editor: Hong et al. (Sept. 24 issue) present results of an early-phase clinical trial of sotorasib, which showed promising clinical benefit. Patients had non–small-cell lung cancer (NSCLC; 46%) or colorectal cancer (33%), and White patients constituted 76% of the cohort. As drugs are being…

Transmission of maternal cancer to offspring is extremely rare and is estimated to occur in approximately 1 infant per every 500,000 mothers with cancer, whereas approximately 1 in 1000 live births involves a mother with cancer. Table 1 provides data on 18 previously reported cases. In these cases,…

Acute graft-versus-host disease (GVHD) remains a major complication and cause of death after allogeneic hematopoietic stem-cell transplantation (HSCT). With the use of standard prophylaxis regimens that include a calcineurin inhibitor with either methotrexate or sirolimus, grade II to IV acute GVHD…

The Covid-19 (coronavirus disease 2019) pandemic effectively stopped cancer screening in the United States. Because the pandemic has also produced severe financial strains both for people and for public budgets, a reassessment of the value of various population-wide screening efforts is warranted…

Pharmacologic methods to prevent acute graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HSCT) have long relied on combinations of immunosuppressive medications and antibodies to inhibit or deplete donor T cells that recognize alloantigens in the recipient. In…

In the United States, race, ancestry, genetics, and medicine are inextricably linked in a complex and fraught history. Medicine is replete with examples of racial injustice inflicted by the use of race and ethnicity as biologic constructs to engender hierarchical discrimination. Race and ethnicity…

Figure 1.

Beck et al. define an adult-onset inflammatory disorder that unites multiple clinical conditions with previously different diagnoses or with no diagnosis at all; their findings are now reported in the Journal. The VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is defined…